EVALUATION OF ALLERGENIC PROPERTIES OF COMPLEX ANTIPARASITIC DRUG “INSPECTOR QUADRO TABS”

The obtained experimental results of the study of allergenic properties of complex insectacaricide drug for veterinary use «Inspector Quadro Tabs» (made by “CJSC SPC Ekoprom”) are shown in this article. The drug contains a new combination of active ingredients – lufenuron, moxidectin and praziquantel. Such a combina-tion has a broad spectrum of antiparasitic action against endo- and ectoparasites. The studies were carried out according to “Methodical Guidelines on evaluation of allergenic properties of pharmaceutical substances” (Guideline on experimental (non-clinical) studies of new pharmaceutical substances). The test was carried out on 20 albino Guinea pigs, the animals were divided into experimental and control groups. Allergization of animals in the experimental group was carried out by oral administration of the drug in minimal dose in the form of suspension in 1-% starch gel within 20 days. The animals were tested in 10 days after the allergization: epiku-tan test, conjunctival test and nasal test. Criteria for evaluation of irritant action of the drug suspension were the following characteristic signs of irritation: reddening of a plaintive channel, erythema, increase in a skin fold, fissures, ulceration, skin temperature, etc. It is established that during the experiment no irritating reactions were noted, the drug doesn't cause an allergization in animals body.