Open AccessTOXICOLOGICAL CHARACTERISTICS OF A VETERINARY ANTI-PARASITIC PREPARATION WITH A PROLONGED ACTION IN THE FORM OF A SOLUTION FOR INTERNAL ADMISSION
Author(s) -
Арисова
Publication year - 2021
Publication title -
theory and practice of parasitic disease control
Language(s) - English
DOI - 10.31016/978-5-6046256-1-3.2021.22.67-73
Subject(s) - acute toxicity , medicine , drug , toxicity , median lethal dose , pharmacology , toxicology , biology
This article presents the results of studies of the toxicological characteristics of a longacting veterinary medicinal product "Neoterica Protecto Syrup" based on moxidectin in the form of an oral solution. Acute oral toxicity was studied in white mice and white rats. As a result, the LD50 of the drug was 4300 mg/kg for male and female mice, 3500 mg/kg for male rats, and 5700 mg/kg for female rats, and on the basis of which it was established that the drug belongs to the 3rd hazard class (moderately hazardous substances) according to GOST 12.1.007-76. Acute cutaneous toxicity was investigated and the irritant effect of the drug on white rats was assessed, for the drug the 4th hazard class (low-hazard substances) was established according to GOST 12.1.007-76. The subchronic toxicity of doses of 1/10, 1/20 and 1/50 of the LD50 of the drug, established in an acute experiment, with daily use for 5 days was studied in white rats. As a result, it was found that doses of 350, 175 and 70 mg/kg with daily use in white outbred rats for 5 days are inoperative.