Open AccessSTUDY OF TOXICOLOGICAL PROPERTIES AND LOCAL IRRITANT EFFECT OF THE DRUGS INSACAR TOTAL C PLUS AND INSACAR TOTAL K PLUS ON LABORATORY RATS
Author(s) -
Makhvatova
Publication year - 2021
Publication title -
theory and practice of parasitic disease control
Language(s) - English
DOI - 10.31016/978-5-6046256-1-3.2021.22.330-335
Subject(s) - anthelmintic , pharmacology , body weight , toxicity , moxidectin , median lethal dose , chemistry , toxicology , medicine , veterinary medicine , biology
The study of acute cutaneous toxicity and local irritant effect of the drugs Insacar Total C Plus and Insacar Total K Plus on mongrel white rats was conducted in doses of 5000 and 10 000 mg/kg of body weight (BW). When the drugs were applied to the skin of rats, no animal deaths were recorded during the entire observation period. Thus, the LD50 is more than 10 000 mg / kg of BW. A single application of the drugs to the skin in rats at a dose of 1 ml/100 g (10 000 units) in two experimental groups on the 7th and 9th day of the study showed the most pronounced irritant effect. In this regard, the drugs have an irritating effect – 1 point.The studied drugs Insacar Total C Plus and Insacar Total K Plus belong to the group of insectoacaricidal and anthelmintic agents. The substances included in its composition have a contact and systemic effect on ectoparasites and nematodes. They are complex medicines containing 4 active components – moxidectin, pyriproxifen, imidacloprid, praziquantel. Such a combination of active substances is characterized by effectiveness against a larger number of parasite species, stages of their development, and in addition, reduce the likelihood of developing resistance of pathogens to drugs.