Open AccessTOXICITY OF THE DRUG DELCID 7.5® WHEN APPLIED TO THE MUCOUS MEMBRANES
Author(s) -
Burmistrova,
Vasilevich,
Deltsov
Publication year - 2021
Publication title -
theory and practice of parasitic disease control
Language(s) - English
DOI - 10.31016/978-5-6046256-1-3.2021.22.104-111
Subject(s) - drug , mucous membrane , piperonyl butoxide , medicine , toxicity , pharmacology , cornea , eye irritation , anesthesia , ophthalmology , irritation , pathology , immunology
The effect of the drug Delcid 7.5® on the mucous membranes of the eyes of rabbits of the Australian White breed, weighing 2–3 kg, which were instilled in the conjunctival cavity of the right eye with 1 drop of the drug. The left eye was a control eye, and distilled water was instilled into it. The studies were conducted according to the score system, based on the total score (according to the classification of A. Majda, K. Chrusaieleska, 1973) according to the following criteria: conjunctival and corneal hyperemia, eyelid edema, discharge at a drug concentration, 10% the degree of severity of the effect in rabbits is weak, at a concentration of 50% – moderate. Experience has shown that a single instillation of the drug Delcid 7.5® into the conjunctival sac at a concentration of 10% does not cause a response, and a 50% concentration causes a moderately irritating effect of the drug on the mucous membranes. The results of the conducted studies show that the insectoacaricidal drug Delcid 7.5® for veterinary use, developed by LLC "NVC Agrovetzashchita", including deltamethrin, piperonyl butoxide, diflubenzuron is safe for rabbits, and therefore it can be recommended for studying the effectiveness of acarosis in rabbits and other animal species.