Study of the Cumulative Properties of the Long-acting Preparation "Flyblock insecticidal tag

The purpose of the research is to study the cumulative properties of the long-acting preparation "Flyblock insecticidal tag". Materials and methods . The cumulative properties of the "Flyblock insecticidal tag" preparation were studied by the subchronic toxicity method on 20 male guinea pigs, which were divided into experimental and control groups of 10 animals each. A solution for impregnating a polymer plate of the preparation "Flyblock insecticidal tag" was applied to the skin, on a previously trimmed area of the coat 4 × 4 cm in size in the spinal column using a disposable syringe for injection in doses from 0.1 to 1.12 LD50. To animals of the experimental group, the drug was applied at a dose of 187.40 mg/kg, equal to 1/10 of the previously established single lethal dose of LD50, then every subsequent 4 days the dose was increased 1.5 times. The control group of animals received 0.9 % saline solution at a dose of 2 ml. For 27 days, the physiological state of the animals, the nature and degree of activity and coordination of movements, the presence of tremors, seizures, paresis, paralysis were assessed; took into account the condition of the hair and mucous membranes, studied the symptoms of intoxication and recorded the death of animals. Dead guinea pigs were subjected to autopsy, detailed examination of the thoracic and abdominal cavities, and macroscopic examination of parenchymal organs and tissues. Results and discussion . When studying the cumulative properties of the preparation "Flyblock insecticidal tag", the value of the cumulation coefficient was set equal to 11.6. In accordance with the classification of chemicals, including pesticides, a prolonged-release drug belongs to the group of substances with a weakly expressed degree of cumulation.