Open AccessLaser doppler flowmetry as the advanced non-invasive method of evaluation оf microcirculation status in patients with diabetes mellitus
Author(s) -
Златослава Олексіївна Шаєнко
Publication year - 2021
Publication title -
klìnìčna endokrinologìâ ta endokrinna hìrurgìâ
Language(s) - English
Resource type - Journals
eISSN - 2519-2582
pISSN - 1818-1384
DOI - 10.30978/cees-2021-4-44
Subject(s) - microcirculation , medicine , diabetes mellitus , microangiopathy , laser doppler velocimetry , intensive care medicine , disease , diabetic neuropathy , pathogenesis , cardiology , blood flow , endocrinology
Currently, the problem of diabetes mellitus (DM) is one of the most important medical and social challenges worldwide. This is primarily due to the widespread prevalence of the disease and tendency to further increase in the incidence of diabetes mellitus.Systemic microcirculatory disorders play an important role in the pathogenesis of DM complications. They lead to the development of microangiopathy and neuropathy through the primary lesion of vessels involved in the blood supply of the peripheral parts of the nervous system. Currently, less than one-third of physicians recognize signs of peripheral neuropathy associated with diabetes. Untimely diagnosis contributes significantly to high morbidity, disability, and mortality.The authorinvestigates the experience of the use of laser Doppler flowmetry (LDF) in clinical practice as a method of studying the state of the microcirculatory bed in patients with diabetes mellitus.LDF is a non-invasive quantitative method of microcirculation assessment; its capabilities include the analysis of microcirculatory rhythms and functional testing with different types of provocative effects, which provides with investigating the state of regulatory mechanisms of microcirculation. The prevention and treatment of various microcirculatory disorders is one of the most important problems of medical practice. The difficulties of studying the microcirculation are caused by the very small size of microvessels and strong ramification of intra-organic vascular networks. The use of LDF in scientific research will make it possible toreveal the DM-specific changes in microcirculatory bed functioning. The findings of some studies suggest that microcirculatory disorders are not only a pathogenetic link in the development of complications, but they are also observed in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes. However, the method has not yet become widespread in clinical practice.