Open AccessEvaluation of potential drug interactions in hospital admission
Author(s) -
Jackeline L. Santos,
Luana R. Spalla,
Selma Rodrigues de Castilho
Publication year - 2020
Publication title -
revista brasileira de farmácia hospitalar e serviços de saúde
Language(s) - English
Resource type - Journals
eISSN - 2316-7750
pISSN - 2179-5924
DOI - 10.30968/rbfhss.2019.101.0384
Subject(s) - medicine , medical prescription , drug , context (archaeology) , documentation , intervention (counseling) , pharmacovigilance , emergency medicine , intensive care medicine , pharmacology , psychiatry , computer science , programming language , paleontology , biology
In clinical practice, drugs association is common and can lead to drug interactions (MI), which can lead to an avoidable adverse events that may need a for pharmaceutical intervention. Objective: The objective of this study is to identify and evaluate the drug interactions present on prescriptions of patients at the adult medical clinic of a hospital in Rio de Janeiro, at admission moment. Method: Cross-sectional study involving the analysis of information through the database (e-sus). Interactions were classified according to the Micromedex database. Results: A total of 177 prescriptions were evaluated. The main underlying disease was the neoplasias (36.16%), and the main cause of hospitalization was pain (8.5%). Of the prescriptions evaluated, 81.93% had some potential MI. A total of 180 types of MI were identified, representing 600 IM. Considering the degree of severity, 60% (358) were classified as severe MI, 38% (229) moderate, 1% (7) low and contraindicated. The most prevalent drug involved in MI was dipyrone (43.8%). The most frequent severe MI was between Dipirona + Enoxaparin (9.4%). Among moderate MI, Dipirone + Captopril (14.8%) was the most frequent and among the low ones, Furosemide + Hydralazine (42.9%). The contraindicated MI appeared in a similar way with 16.7% each. According to the scientific evidence found, serious MI had mostly reasonable documentation (59.5%), while the moderate ones had the majority of documentation classified as good (48.9%). Conclusion: In this context it is reasonable to consider that the pharmaceutical analysis of prescription at the patient admission may contribute to preventing drug-related adverse events.