Open AccessA Systematic Review Discussing Biomarkers for Early or Pre-Alzheimer’s Disease for Clinical Diagnosis
Author(s) -
Ishaan Ishaan Bharadwaj
Publication year - 2021
Publication title -
apd trove journal
Language(s) - English
Resource type - Journals
ISSN - 2591-7536
DOI - 10.30943/2021/22112021
Subject(s) - disease , medicine , dementia , intensive care medicine , biomarker , bioinformatics , pathology , biology , biochemistry
Alzheimer’s is a progressive neurodegenerative disease that usually starts slowly and gradually worsens over time. It constitutes for over 65% of dementia cases and currently has no cure. This paper reviews the biomarkers for Alzheimer’s Disease (AD) and evaluates these biomarkers based on various pathologies they are associated with, using the International Working Group (IWG) criteria, sensitivity, specificity etc. This paper summarizes the existing biomarkers, critically compares them and highlights which biomarkers are most effective for clinical diagnosis. It also discusses some of the drawbacks associated with using some biomarkers, either alone or in combination with others