Open AccessSOLID PSEUDOPAPILLARY NEOPLASM OF THE PANCREAS MIMICKING LOW GRADE NEUROENDOCRINE TUMOR
Author(s) -
Thiago Bassaneze,
Clovis Augusto Borges do Nascimento,
Adam Hiar,
Laura Silveira Tanisaka,
Beatriz Villas-Boas Weffort,
Larissa Mariana Ayde,
Maria Laura Kachan Bordig,
Abner Jorge Jácome Barrozo
Publication year - 2022
Publication title -
relatos de casos cirúrgicos
Language(s) - English
Resource type - Journals
ISSN - 2527-2039
DOI - 10.30928/2527-2039e-20223118
Subject(s) - medicine , neuroendocrine tumors , pancreas , pancreatic tumor , differential diagnosis , radiology , fine needle aspiration , biopsy , lesion , endoscopic ultrasound , immunohistochemistry , pathology , pancreatic cancer , cancer
Solid pseudopapillary neoplasms (SPN) and pancreatic neuroendocrine tumors (NET) are rare diseases that are generally incidental findings in imaging tests. SPN is a low-grade tumor with good prognosis that more commonly affects young female patients. Pancreatic NET has a significant variability in outcomes, with low malignant potential in non-progressing tumors that are welldifferentiated. Both tumors may appear very similar in imaging tests and immunohistochemical (IHC) evaluation, which makes the differential diagnosis challenging, especially in small lesions. Case report: The authors present the case of a 34-year-old male with a medical history of a primary mediastinal germ cell tumor. The patient had no symptoms. Follow-up abdominal CT scan evidenced a single, well-delimited nodular lesion in the pancreatic neck, measuring 17mm in diameter. The patient was submitted to an endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) and after IHC analysis, there was a diagnostic suspicion of low-grade pancreatic NET. Central pancreatectomy (CP) was performed and complete lesion analysis evidenced a pancreatic SPN. Conclusion: The SPN can mimic low-grade nonfunctioning pancreatic NETs in imaging tests and EUSFNA IHC evaluation.