Effect of silver and dimethyl sulfoxide nanoparticles on antibiotic resistance of microorganisms in the treatment of purulent-catarrhal endometritis in cows

The increase in the production of livestock products, along with the improvement of the breed and productive qualities of animals, is closely related to the state of reproduction of the herd. The main factor holding back the reproduction of the herd to a large extent is the presence of acute postpartum endometritis. The study was carried out in order to study the species composition of microorganisms, the change in their antibiotic sensitivity during therapy after generic purulent-catarrhal endometritis of cows from 2019 to 2020. in the economy of the Novosibirsk region during the period of mass calving with a preparation containing silver nanoparticles in comparison with an antibacterial preparation. The animals were divided into experimental and control groups on the basis of analogs. The experimental group (n = 42) was injected intrauterinely with the drug, where the complex of drugs argovit, Dimexide in the form of 10% and 5% aqueous solutions at a dose of 0.3 ml / kg of live weight was used as an antibacterial drug once every 48 hours, and uteroton was intramuscularly 0 , 02 ml / kg live weight, once, once every 48 hours. The cows of the control group (n = 42) were injected with fish oil intrauterinely (0.3 ml / kg of live weight) with oxytetracycline hydrochloride (40 mg / kg of live weight), once every 48 hours and intramuscularly uteroton 0.02 ml / kg of live weight , once, once every 48 hours. The research results showed that the use of the drug argovit containing silver nanoparticles + DMSO caused a pronounced increase in antibiotic sensitivity in the isolated microflora in postpartum purulent-catarrhal endometritis of cows.