Open AccessAntibiotic Dosing in Chronic Kidney Disease
Author(s) -
N. D. Bunyatyan,
В. И. Петров,
О. В. Шаталова,
А. В. Пономарева,
A. Yu. Ryazanova,
В. С. Горбатенко,
А. С. Герасименко,
Е. А. Сокова
Publication year - 2021
Publication title -
vedomosti naučnogo centra èkspertizy sredstv medicinskogo primeneniâ
Language(s) - English
Resource type - Journals
eISSN - 2619-1172
pISSN - 1991-2919
DOI - 10.30895/1991-2919-2021-11-4-239-245
Subject(s) - dosing , medicine , renal function , kidney disease , antibiotics , medical prescription , intensive care medicine , pharmacokinetics , kidney , pharmacology , biology , microbiology and biotechnology
Infectious process is an important cause of morbidity and mortality among patients with chronic kidney disease. Prescription of antibacterial drugs should take into account the pharmacokinetic parameters of the medicine and the individual characteristics of the patient. Adequate antibiotic dosing is crucial for positive treatment outcome and minimisation of side effects. The aim of the study was to analyse scientific literature on factors affecting the dosing of antibacterials in patients with chronic kidney disease. Since most antibacterial medicines are eliminated by the kidneys, a decrease in glomerular filtration rate or kidney function should be followed by the dose adjustment in order to prevent the medicine accumulation and reduce the risk of side effects. Antibiotic dosing in such patients should be accompanied by kidney function assessment and be adjusted to ensure effective and safe treatment, as well as prevention of bacterial resistance. The review provides data on the dosing of some antibiotic groups (beta-lactams, aminoglycosides, fluoroquinolones) at different creatinine clearance rates. Extrarenal excretion of medicines does not usually require the dose adjustment in patients with chronic kidney disease.