Open AccessAKTIVITAS ANTIMALARIA SENYAWA FLAVANON TERISOPRENILASI DARI KULIT BATANG Erythrina fusca L.
Author(s) -
Novi Fatmawati,
Novi Anggreini,
Ratih Dewi Saputri,
Tjitjik Srie Tjahjandarie,
Mulyadi Tanjung
Publication year - 2018
Publication title -
jurnal kimia mulawarman
Language(s) - English
Resource type - Journals
eISSN - 2476-9258
pISSN - 1693-5616
DOI - 10.30872/jkm.v16i1.586
Subject(s) - erythrina , plasmodium falciparum , chemistry , strain (injury) , stereochemistry , traditional medicine , biology , botany , medicine , malaria , anatomy , immunology
Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity.