Open AccessJustification of the choice of diosmin vasoprotective as a preventive agent of pre-eclampsia
Author(s) -
Н.О. Фролова,
Ю В Тезиков,
И. С. Липатов
Publication year - 2021
Publication title -
reproductive health of woman
Language(s) - English
Resource type - Journals
eISSN - 2708-8731
pISSN - 2708-8723
DOI - 10.30841/2708-8731.1.2021.229710
Subject(s) - vasoprotective , diosmin , medicine , placental insufficiency , placenta , eclampsia , obstetrics , fetus , pregnancy , gynecology , nitric oxide , pathology , biology , alternative medicine , hesperidin , genetics
In this study, the effectiveness of vasoprotective Diosmin for the prevention of pre-eclampsia in pregnant women of high-risk group with severe forms of placental insufficiency was evaluated. The choice of prophylactic agent in the clinical group is justified by close pathogenetic relationship between placental insufficiency and pre-eclampsia on the one hand, and proved fetoprotective action of Diosmin in case of placental insufficiency on the other hand. It is shown that a normalizing effect on the uterine-placental- fetal blood flow, the functional state of the endothelium of blood vessels, the production of growth factors, the induction of apoptosis of immunocompetent cells by trophoblasts, metabolism and angiogenesis in the placenta, contributes to clinically significant reduction in the frequency of implementation of fetoplacental complex pathology and pre-eclampsia.