Open AccessSynthesis, Characterization and evaluation of Anti-inflammatory and Analgesic activity of Benzothiazole derivatives
Author(s) -
Abhay Kumar Verma,
Alex Martín,
Arun Kumar Singh
Publication year - 2014
Publication title -
indian journal of pharmaceutical and biological research
Language(s) - English
Resource type - Journals
ISSN - 2320-9267
DOI - 10.30750/ijpbr.2.3.14
Subject(s) - benzothiazole , acetanilide , chemistry , analgesic , anti inflammatory , benzoic acid , organic chemistry , combinatorial chemistry , nuclear chemistry , pharmacology , medicine
A parent benzothiazole nucleus was synthesized by para amino acetanilide, then it is subjected to treatment with various substituted aromatic aldehydes to get the corresponding Schiff’s bases followed by treatment with pthalic anhydride to form 2-(6- acetamidobenzo[d]thiazol-2-ylcarbamoyl)benzoic acid. The structures of synthesized compounds were confirmed by various spectroscopic methods such as IR, 1H NMR and mass spectroscopy. The products were evaluated for their anti-inflammatory and analgesic activities. Some of the compounds exhibited potent activities when compared with the standards.