Open AccessAntidiabetic Effect of Pleurotus ostreatus (Jacq.ex Fr) kumm. Mushroom on Alloxan-induced Diabetic Rats.
Author(s) -
Imoh I. Johnny,
Joseph Okon
Publication year - 2013
Publication title -
indian journal of pharmaceutical and biological research
Language(s) - English
Resource type - Journals
ISSN - 2320-9267
DOI - 10.30750/ijpbr.1.2.6
Subject(s) - pleurotus ostreatus , alloxan , mushroom , traditional medicine , metformin , body weight , medicine , diabetes mellitus , pleurotus , pharmacology , chemistry , food science , endocrinology
Antidiabetic effects of ethanolic extract of Pleurotus ostreatus (mushroom) on alloxan-induced diabetic rats was studied. The median lethal dose (LD50) of the extract was determined to be 3,472.14 mgkg-1 and a single dose of 380.0, 760.0 and 1140.0 body weight of the extract were intraperitoneally administered as the treatment dose and the blood glucose levels (BGL) examined for 7 hours and 15 hours (prolonged) at 2 and 4 hours intervals respectively. The extract exhibited significant (p 0.05 and p 0.01) reduction in the blood glucose levels of the albino rats. The extract compared favourably with the standard reference drug (metformin) which all gave their maximum BGL reduction at 5 hours duration. The confirmation of antidiabetic potentials of the Pleurotus ostreatus tuber has been justified in this study as claimed by traditional medicine practitionersin Akwa Ibom State.