
Restricted Access Molecularly Imprinted Polymers for Biological Sample Preparation
Author(s) -
Tássia Venga Mendes,
Mariana Azevedo Rosa,
Eduardo Costa Figueiredo
Publication year - 2021
Publication title -
brjac brazilian journal of analytical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.131
H-Index - 6
eISSN - 2179-3433
pISSN - 2179-3425
DOI - 10.30744/brjac.2179-3425.rv-90-2021
Subject(s) - molecularly imprinted polymer , polymer , molecular imprinting , monomer , solid phase extraction , materials science , nanotechnology , sample preparation , macromolecule , extraction (chemistry) , molecular recognition , chromatography , selectivity , combinatorial chemistry , chemistry , molecule , organic chemistry , biochemistry , catalysis , composite material
Restricted access molecularly imprinted polymers (RAMIPs) have been efficiently used for the extraction of small organic molecules from untreated biological matrices (e.g. blood, plasma, serum, and milk). These materials have been obtained by modifying the external surface of conventional molecularly imprinted polymers (MIPs) with hydrophilic monomer grafting, crosslinked protein capsule or a combination of both. These sorbents aggregate the selectivity of MIPs with the ability to exclude macromolecules of restricted access materials (RAMs), being widely employed in solid phase extraction techniques, beyond their use in sensors. In this review, we discuss about the design and application of RAMIPs in biological sample preparation, emphasizing the future trends and remaining challenges of this technology for bioanalyses.