Open AccessKajian Peran Gen P53 dalam Tumorigenesis
Author(s) -
Retina Yunani
Publication year - 2018
Publication title -
vitek
Language(s) - English
Resource type - Journals
eISSN - 2685-8894
pISSN - 2460-9773
DOI - 10.30742/jv.v6i0.27
Subject(s) - carcinogenesis , cancer research , biology , cell cycle , gene , tumor suppressor gene , cell cycle checkpoint , dna damage , metastasis , apoptosis , transcription factor , suppressor , microbiology and biotechnology , dna , cancer , genetics
Gene p53 is a tumor suppressor gene that in normal conditions is in ' standby ' mode , several studies show that pivotal point that lead to stimulation of p53 is DNA damage , heat shock , hypoxia, exposure of nitric oxide ( NO ) , the expression of oncogenes and some p53 pathways activation. p53 mechanism as a guardian of genome stability are cell cycle arrest, repair of DNA damaged, induce apoptosis, prevents angiogenesis , invasion and metastasis ability of the tumor. On many tumor , p53 is not loss , but mutated , the p53 mutant was expressed 70 % in lung cancer , and in different frequencies in other cancers . Then the role of p53 as a transcription factor that works to regulate genes involved in tumor suppression is indispensable .