Open AccessInterleukin-6 (IL-6) Level as an Indikator of Progresivity Rheumatoid Arthritis (RA) Disease
Author(s) -
Putu Oky Ari Tania,
Dorta Simamora,
Wahyuni Dyah Parmasari,
Febtarini Rahmawati
Publication year - 2017
Publication title -
jurnal ilmiah kedokteran wijaya kusuma
Language(s) - English
Resource type - Journals
eISSN - 2580-5967
pISSN - 1978-2071
DOI - 10.30742/jikw.v3i1.44
Subject(s) - rheumatoid arthritis , medicine , interleukin 6 , immunology , arthritis , autoimmune disease , stage (stratigraphy) , disease , inflammation , interleukin , cytokine , biology , paleontology
Rheumatoid Arthritis (RA) is autoimmune disease that attacks joints and synovial tissues. Rheumatoid Arthritis is characterized by inflammation that involves production of cytokines such as Interleukin 6 (IL-6). Increasing of interleukin 6 has correlation with activity and progressivity of the disease. This research was designed to know whether IL- 6 could be used as indicator progressivity of RA. The method that used for measuring IL-6 level is ELISA (Enzyme Linked Immunosorbent Assay), using the principle antigen-antibody binding. In early stage there were 9 persons (S01, S02, S03, S04, S07, S08, S09, S10 and S14) with of IL-6 level (mean : 3.640 pg/mL), intermediate stage there were 3 persons (S06, S13 and S15) with IL-6 level (mean : 12.453 pg/mL), late stage : 3 persons (S05, S11 and S12) with IL-6 level (mean : 59.349 pg/mL).