Preoperative HE4 Tumor Marker and Prognostic Factors in Endometrial Cancer: Review Article

Purpose of the Review: The aim of the review is to summarize the current evidence of HE4 tumor marker as a prognostic marker of endometrial cancer since it is a novel and not yet validated marker in the management of this neoplasm. Recent Findings: HE4 has been studied as a preoperative prognosis marker and the result is encouraging as it is statistically related to unfavorable prognostic markers in endometrial cancer. Having a preoperative marker that relates with prognosis is a non invasive and cost-effective way to classify the patients before the surgery act. Summary: Clinicians could use HE4 as a prognostic marker to help them in the preoperative decision-making process. Thus, good prognostic patients with a low serum HE4 could have a less invasive surgery avoiding lymphadecnectomy which decrease the morbidity of the procedure and reducing the operative time.