Pengaruh Ekstrak Daun Jeruju (Acanthus ilicifolius) terhadap Penurunan Kadar LDL Darah pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Diabetes yang Diinduksi Aloksan

Background : DM is a chronic disease that has long-term complications. Alloxan is a fast way to produce experimental diabetic (hyperglycemic) in animal experiments related to elevated LDL. Jeruju ( Acanthus ilicifolius ) is a low-growth herbaceous plant that easily grows containing secondary metabolites such as Alkaloids, Saponins, Flavonoids, Terpenoids, and Phenols. Objective : To determine the effect of jeruju leaf extract on the decrease in blood levels of LDL of male Wistar rat ( Rattus norvegicus ) induced Alloxan. Methods : This research is an experimental laboratory type with Post Test Only Control Group Design. The sample using 24 rats, which were divided into 3 groups: negative control group (K-) were given standard feed; positive control group (K +) induced alloxan 120 mg/kgBW on 1 st day; the treatment group (P) induced alloxan 120 mg/kgBW on 1 st day and was given jeruju leaf extract 67.2 mg/kgBW on 5 th -14 th day. The 15 th day a blood sample was taken to determine LDL levels. Result : The results of One-Way ANOVA test showed an insignificant mean difference (p = 0.270) in LDL level of K- (   = 9.75 mg/dl) and the K+ (   = 11.38 mg/dl ). Insignificant mean difference (p = 0.270) in P (   = 9 mg/dl) with blood LDL levels in the K+ (   = 11.38 mg/dl) and the K- (   = 9, 75 mg/dl). Conclusion :    Giving alloxan can increase blood levels of LDL and administration of jeruju leaf extract can reduce blood levels of LDL in experimental animals but not statistically significant.   Keywords : Alloxan, LDL, Acanthus ilicifolius .