Pemberian Ekstrak Buah Pare dan Diet Tinggi Lemak pada Penurunan Berat Badan Tikus Putih Jantan

Abstra ct Background : Obesity is an energy balance disorder, ketogenic diet can reduce body weight. Bitter melon ( Momordica charantia L.) is a type of vegetable material that is often used as an antioxidant, hypocholesterolemia and hypotriglyceridemia drug. Cucurbitasin is a substance produced by bitter melon ( Momordica charantia L.) with a bitter taste which causes in decreasing appetite, resulting in a decrease in triglycerides. This is caused by the bioactivity of bitter melon ( Momordica charantia L.) which can increase lipid oxidation, which causes the accumulation of decreased fat tissue which can reduce weight. Methods : This research using pre and post test randomized controlled group design with sample size of 30 male white rats ( Rattus norvegicus ) wistar lines divided into 3 groups, group 1 as negative control group given standard feed, group 2 as positive control group given high-fat diet with a dose of 2.5 ml and group 3 as a treatment group given a high-fat feed with dose of 2.5 ml and extract of bitter melon ( Momordica charantia L.) at dose of 37.5 mg / 150 gBB by feeding tube every morning for 28 days. Data were analyzed by T-paired tests. Result : The T-paired test in each group found a significantly different result of p = 0,000. Conclusion : given bitter melon ( Momordica charantia L.) extract and high-fat diet can reduce weight in male white rats ( Rattus norvegicus ).   Keywords :Bitter molon extract, high fat feed, weight loss.