Pengaruh Pemberian Ekstrak Daun Mahkota Dewa pada Gambaran Histopatologi Paru Tikus Putih yang Dipapar Asap Rokok

Background : Smoking is a bad habit for health. There are many dangerous components inside a cigarette. The smoke that comes out from the cigarette contains many harmful components. Smoking and getting exposed to cigarette smoke in a long period of time can cause inflammatory response on respiratory tract. Mahkota dewa leaf contains beneficial biological component, such as  flavonoid ,  alkaloid , and saponin  that have anti-inflammatory, anti-cancer, and many others. Aim : The purpose of this research was to determine the effect of administration of mahkota dewa leaf ( Phaleria macrocarpa ) extract onlung histopathology in white male Wistar rats ( Rattus norvegicus ) exposed to cigarette smoke. Methods :  This research is a true laboratory experimental research using  Post-Test Only Control Group Design . The subject in this research were 30 male Wistar Rats ( Rattus norvegicus ) which were divided into 4 groups, a group without given any treatment (K-), a group where they only getting exposed to cigarette smoke (K+), a group where they exposed to cigarette smoke and given mahkota dewa leaf extract at 1500 mg/kgBW/day dose (Eg1), and the group exposed to cigarette smoke and a mahkota dewa leaf extract at a 2500 mg/kgBW/day dose (Eg2). Result:  1.) There was a significant difference on lung histopathology between K- and K+, Eg1, and Eg2. 2.) There was no significant difference on lung histopathology between K+, Eg1 and Eg2. Conclusion :  Exposure to 5 cigarette smoke in 21 days caused lung histopathology changes. However, there was no effect of the administration of mahkota dewa leaves extract at 1500 mg/kgBW/day and 2500 mg/kgBW/day on lung histopathology of white male Wistar rats exposed to 5 cigarette smoke in 21 days. Keyword :  Phaleria macrocarpa leaf,  Flavonoid, Alkaloid, cigarette smoke, inflammatory response, Infiltration of Inflammatory cells.