Open AccessSerotonin Theory of Depression: Modern View
Author(s) -
V. M. Kovalzon
Publication year - 2020
Publication title -
rossijskij nevrologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.104
H-Index - 4
eISSN - 2686-7192
pISSN - 2658-7947
DOI - 10.30629/2658-7947-2020-25-3-40-44
Subject(s) - serotonin , depression (economics) , morning , psychology , sleep (system call) , sleep deprivation , medicine , neuroscience , psychiatry , anesthesia , developmental psychology , circadian rhythm , computer science , keynesian economics , receptor , economics , operating system
In development of the «serotonin» hypothesis of depression put forward by I.P. Lapin and G.F. Oxenkrug in 1969, the combination of the two factors is proposed which are responsible for depression formation: reduced “basal” 5-HT cerebral level and excessive duration of early morning REM sleep periods during which the release of cerebral serotonin ceases altogether. As a means of prevention and treatment, not the deprivation, but rather fragmentation of REM sleep is proposed, which is much easier for patients to tolerate.