Open AccessINFLUENCE OF SINGLE NUCLEOTIDE POLYMORPHISMS OF “ZINC FINGERS” PROTEINS GENES ON MULTIPLE SCLEROSIS
Author(s) -
E. E. Arbuzova,
N. V. Selyanina,
А В Кривцов
Publication year - 2019
Publication title -
rossijskij nevrologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.104
H-Index - 4
eISSN - 2686-7192
pISSN - 2658-7947
DOI - 10.30629/2658-7947-2019-24-3-19-23
Subject(s) - multiple sclerosis , single nucleotide polymorphism , haplotype , gene , genotype , zinc finger , genetics , biology , medicine , immunology , transcription factor
The genes ZFAT and ZFHX4 encoding the zinc finger proteins were previously identified as predisposing to autoimmune pathology and various cancer diseases, as well as influencing on therapeutic effect of interferonbeta in patients with multiple sclerosis. The aim of the study is to determine the associations of single nucleotide polymorphisms rs11787532 ZFHX4 and rs733254 ZFAT and development and severity of clinical manifestations of multiple sclerosis in Perm krai. A significant predominance of the C/A genotype of rs733254 ZFAT gene, and GC and CC haplotypes in people with multiple sclerosis was found. The association of single nucleotide polymorphisms with the severity of clinical manifestations of multiple sclerosis was not detected.