Open AccessExperience with the use of glucocorticoids and netakimab in the treatment of patients with COVID-19 in outpatient settings
Author(s) -
Р. Е. Павлов,
С. В. Царенко,
А. В. Секинаева,
П. Н. Рыбин,
М. В. Нагибина,
Е. В. Сошникова,
М. С. Климова
Publication year - 2020
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.30629/0023-2149-2020-98-6-449-455
Subject(s) - medicine , betamethasone , covid-19 , oxygen therapy , pharmacotherapy , betamethasone dipropionate , combination therapy , anesthesia , disease , infectious disease (medical specialty)
Goal.Tostudythe e cacyand safety of therapy with netakimab (NTK) and the complex drug — betamethasone dipropionate +betamesone phosphate (B) in patients with COVID-19 in outpatient settings. Materialand methods. A retrospective analysisof the treatment of 12 patients with severe new coronavirus infection who received therapy was performed simultaneously withnetakimab (NTK) (the first administration at a dose of 60–120 mg, if indicated-the second administration at a dose of 60 mg)and a combined drug-betamethasone dipropionate + betamesone phosphate (B), at a dose of 2 ml o cialsolution.Treatmentwas performed at 7th (95% CI [6; 10]) day from the beginning of the disease. Repeated administration of NTK was performedin older patients due to insu ciente ectof stopping hyperthermia and/or hypoxemia. A comprehensive examination of patientsbeforeand after NTK + B therapy was performed, which included clinical (assessment of the severity and duration of fever,analysis of gas exchange indicators), instrumental (computed tomography of the lungs) and laboratory methods, includingdetermination of ferritin, IL-6. Results. Simultaneous use of NTK + B therapy resulted in compensation of hyperthermia and/orSpO 2 > 93% 2.5 (95% CI [1; 3]) days after the first administration, a significant decrease in the level of inflammatory markers,and positive dynamics according to lung CT data. In all cases, increased respiratory support or additional antibiotic therapy,as well as hospitalization, were not required. The search for articles on the topic was carried out in the PubМed database inEnglish and Russian, published in the period from 2001 to 2020.