Уровень пресепсина у больных тяжелой пневмонией и пневмогенным сепсисом на гемодиализе

2 Altai Regional Clinical Hospital, 656024, Barnaul, Russia Theaimof this study was to evaluate presepsin to improve diagnosis of severe pneumonia, sepsis in patients on hemodialysis.Materialand methods. 62 patients with severe pneumonia, sepsis, chronic glomerulonephritis and nephropathy aged from 17to 77 years were examined. Among them were 19 patients who received hemodialysis. These patients have been investigatedfor the level of the presepsin. Presepsin level was quantified on immunohemilyuministsentny analyzer Pathfast (MitsubishiChemical Medience Corporation, Japan) in pg/ml.Results. Рresepsinat the group of patients with severe pneumonia who received hemodialysis was 6587.9 ± 2011.09 pg/ml(n = 7), рresepsin at the group of patients with pneumogenic sepsis who received hemodialysis was 6931.1 ± 820.46 pg/ml(n = 7). Рresepsin at the group of patients with chronic glomerulonephritis and nephropathy who received hemodialysis was 1693.0 ± 248.24 pg/ml (n = 5). There was no di erencebetween the presepsin level at the groups of patients with severepneumonia, pneumogenic sepsis who received hemodialysis. The presepsin at the group of patients with severe pneumonia,pneumogenic sepsis who received hemodialysis was above the the level of presepsin at the group of patients with chronicglomerulonephritis and nephropathy who received hemodialysis.Conclusion. Thehigh level of presepsin is an indication of an active infectious disease and the e ectof hemodialysis.