Open AccessEctopic fat depots as a factor of cardiovascular risk in patients with nonalcoholic fatty liver disease
Author(s) -
М. Е. Стаценко,
С В Туркина,
И. А. Тыщенко,
Е Е Горбачева
Publication year - 2021
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.30629/0023-2149-2020-98-11-12-759-765
Subject(s) - medicine , nonalcoholic fatty liver disease , fatty liver , adipose tissue , disease , risk factor , bioinformatics , endocrinology , biology
Thereviewrepresentsevaluation of the ectopic fatty depots effect on the development of cardiovascular diseases (CVD)in patients with nonalcoholic fatty liver disease (NAFLD). Nowadays, NAFLD is the most common cause of chronic liverdisease in most countries of the world. A number of studies have confirmed the important role of NAFLD in the formation andprogressionof CVD, which is manifested by an increased risk of cardiovascular events in patients with NAFLD according toFraminghamRisk Score. The statement that NAFLD should be recognized as an independent risk factor for CVD, in additionto other metabolic disorders, is often confirmed. One of the possible mechanisms of interrelation between NAFLD and CVDis the paracrine activity of visceral adipose tissue; the possibility of local effects of various ectopic depots of visceral fat isbeing discussed. There is no doubt that epicardial adipose tissue plays an important role in the formation of the hepato-cardiaccontinuum. Тhere are more and more studies evaluating the effect of other ectopic depots on the development of CVD inpatients with NAFLD. The article provides an analysis of publications devoted to the interrelation between fatty ectopic depotsand CVD risks in patients with NAFLD. MedLine and PubMed databases in English and Russian languages were used for thesearch.Thereviewincludes articles published from 2000 to 2020.