Open AccessResearch advance on the relationship between Wee1 and tumor genesis and progression
Author(s) -
Ying Yin,
Guohua Yu
Publication year - 2021
Publication title -
journal of oncology research
Language(s) - English
Resource type - Journals
ISSN - 2630-5267
DOI - 10.30564/jor.v3i1.2851
Subject(s) - wee1 , mitosis , cell cycle , cell cycle progression , g2 m dna damage checkpoint , chek1 , cancer research , cell cycle checkpoint , biology , microbiology and biotechnology , cyclin dependent kinase 1 , genetics , cell
In the process of biological genetic information transmission, complete and correct genetic information can make cell mitosis proceed normally. In the development of most tumor cells, G2/M cell cycle checkpoint becomes the key checkpoint in the process of mitosis due to the lack of G1/S cell cycle checkpoint, which mainly depends on the abnormal DNA information blocked by Wee1 protein kinase in G2 phase to enter M phase and prolong the time of G2 phase to complete DNA sequencing So that the normal genetic information can be passed on. Wee1 protein kinase expression is significantly increased in most tumor cells, making it a potential target for tumor therapy.