Open AccessResearch Progress on the Relationship between Polymorphism and SLE of Vitamin D Metabolic Pathway Related Gene
Author(s) -
Rui Han,
Yuxuan Wang,
Guanlu Li,
Yiyu Cai,
Zhilu Li,
Yaqi Huang,
Saijia Li,
Pingping Yan
Publication year - 2021
Publication title -
journal of human physiology
Language(s) - English
Resource type - Journals
ISSN - 2661-3859
DOI - 10.30564/jhp.v3i1.2852
Subject(s) - immune system , biology , vitamin d and neurology , gene , heredity , gene polymorphism , immunology , autoimmunity , vitamin , endocrinology , medicine , allele , genetics
Vitamin D is a class of hormones necessary to maintain normalphysiological activities of the body. A large number of studies have shownthat vitamin D, as a fat-soluble vitamin, is not only related to calcium andphosphorus metabolism, but also closely related to immune regulation,humoral regulation, cell cycle and so on. Systemic Lupus erythema-Tosus(SLE) is a specific autoimmune diffuse connective tissue disease thatcauses tissue and organ damage under the joint action of multiple factorssuch as environment and heredity. Among many factors, the vitamin Dmetabolism pathway gene is particularly important for its influence. Someliterature has shown that the genetic polymorphism of vitamin D metabolicpathway genes is correlated with SLE. Therefore, by referring to relevantliterature, this paper summarized the progress in the research on themechanism of genetic polymorphism of vitamin metabolism pathway genesand the development of SLE.