Open AccessMetformin and Lactic Acidosis in Diabetic Patients
Author(s) -
Baiyan Zhao,
Zhilu Li,
Zhangyi He,
Xinxin Zhou,
Yiying Yu,
Kerong Ren,
Pingping Yan
Publication year - 2021
Publication title -
journal of endocrinology research
Language(s) - English
Resource type - Journals
ISSN - 2630-5224
DOI - 10.30564/jer.v3i1.2849
Subject(s) - metformin , lactic acidosis , medicine , diabetes mellitus , type 2 diabetes , type 2 diabetes mellitus , acidosis , drug , risk factor , endocrinology , pharmacology
Metformin is the basic drug in the clinical treatment of Diabetes, often used in the treatment of Type 2 Diabetes Mellitus (T2DM).Its effect has been fully verified in the clinical treatment of T2DM. However, in the treatment of T2DM with metformin, there is still a certain probability of related lactic acidosis, and the fatality rate is high. Therefore, is the use of metformin drug treatment a direct risk factor for lactic acidosis in diabetic patients? This paper will review the hypoglycemic mechanism of metformin and related studies on lactic acidosis, so as to further explore the relationship between metformin and lactic acidosis in diabetic patients, and provide help and reference for metformin drugs in the clinical treatment of T2DM.