Open AccessLong-chain Brønsted Acidic Ionic Liquids Catalyzed one-pot three-component Biginelli Reaction under Solvent-Free Conditions
Author(s) -
Ling He
Publication year - 2019
Publication title -
journal of advances in medicine science
Language(s) - English
Resource type - Journals
eISSN - 2591-7617
pISSN - 2591-7609
DOI - 10.30564/jams.v2i2.535
Subject(s) - biginelli reaction , thiourea , ionic liquid , catalysis , chemistry , toluene , organic chemistry , urea , solvent , reusability , software , computer science , programming language
A series of halogen-free quaternary ammonium Brønsted acidic ionic liquids (ILs) were prepared and used for Biginelli reaction among aromatic aldehydes, urea or thiourea and β-dicarbonyl compounds. The influencing factors, such as the type and amount of catalyst, solvent, reaction time and reaction temperature, were investigated. The results demonstrated that the 3-(N,N-dimethylhexadecylammonium) propanesulfonic acid toluene sulfate ([DHPA][Tos]) provide the best catalytic activity, with good catalytic performance and reusability under solvent-free conditions. A possible mechanism that accounted for the [DHPA][Tos]-catalyzed reaction was proposed.