Open AccessStudy the ultrastructure changes in the liver of mice post infection with Listeria monocytogenes
Author(s) -
Zainab Ismail Ibrahim
Publication year - 2017
Publication title -
the iraqi journal of veterinary medicine/al-maǧallaẗ al-ṭibbiyyaẗ al-bayṭariyyaẗ al-’irāqiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2410-7409
pISSN - 1609-5693
DOI - 10.30539/iraqijvm.v41i1.99
Subject(s) - listeria monocytogenes , histopathology , ultrastructure , necrosis , biology , microbiology and biotechnology , listeria , pathology , medicine , bacteria , anatomy , genetics
Listeria monocytogenes has important medical health infection in human and animals. The present study aimed to investigate the significant ultrastructure changes occurred in liver post-infection by pathogenic strain of Listeria monocytogenes. Twenty-six mice of both sexes divided into two groups; 1st group (n=21) infected with 0.2 ml (2x109 CFU/ml) of Listeria monocytogenes I/P and 2nd group (n=5) served as negative control group, all animal of both groups sacrificed at 2, 4, 6 and 24 hours post infection (7 mice for each time of infected group). The histopathology of liver tissues post infection revealed degenerative changes and severe necrosis in hepatic lobules exclusively at 6 and 24 hours also there were significant ultrastructure changes of hepatocytes; degeneration and necrosis of hepatocytes appeared at 2 hours post infection.