Open AccessStudy Antidiabetic Effect of Momordica Charantia (bitter gourd) seeds on Alloxan Induced Diabetic Rats
Author(s) -
Auroba M. S. Ibrahem,
Nibras N. A. Al-Abassi
Publication year - 2010
Publication title -
the iraqi journal of veterinary medicine/al-maǧallaẗ al-ṭibbiyyaẗ al-bayṭariyyaẗ al-’irāqiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2410-7409
pISSN - 1609-5693
DOI - 10.30539/iraqijvm.v34i1.675
Subject(s) - momordica , glibenclamide , bitter gourd , alloxan , traditional medicine , diabetes mellitus , aqueous extract , oral administration , medicine , chemistry , pharmacology , endocrinology
The aim of the present study is to investigate the antidiabetic effect of the aqueous extract of Momordica charantia seeds in alloxan - induced diabetic rats. Forty male albino Wistar rats were used, divided randomly into four groups (10 each). Oral administration of the seed extract at a dose of 150 mg/kg B.W. for 30 days showed a significant decrease in fasting blood glucose. Our results were greatly lower after oral administration of aqueous extract of Momordica charantia seeds in alloxan- induced diabetic groups than glibenclamide treated group. Also Momordica charantia extract and glibenclamide administered rats showed progressive increase in body weight