Open AccessEfficacy of Nano Composite Porous 3D Scaffold of Crab Shell and Al-Kharit Histological and Radiological for Bone Repair in Vivo
Author(s) -
Saad H. Zebon
Publication year - 2020
Publication title -
the iraqi journal of veterinary medicine/al-maǧallaẗ al-ṭibbiyyaẗ al-bayṭariyyaẗ al-’irāqiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2410-7409
pISSN - 1609-5693
DOI - 10.30539/ijvm.v44i2.973
Subject(s) - scaffold , bone healing , tibia , biomedical engineering , materials science , shell (structure) , anatomy , dentistry , medicine , composite material
The present study was conducted to evaluate the effect of scaffold fabricated from Nano crab shell and Al-kharit (Papyrus Vaccine) for enhancing the healing of the experimentally induced bone defect in dogs. For this purpose, twenty healthy adult mongrel dogs were used in this study which divided randomly into two equal groups, under general anesthesia, 1 cm bone gap was created in the distal part of the tibia, that fixed by bone plate and screws. Nano crab shell scaffold was implanted. All experimental animals showed normal situation without any infection at the site of operation, while the radiography showed a periosteal and endosteal reaction. Moreover, the gaps were bridged faster in the treated group as compared with the control group. Treated animals showed new bone formation which represented by obvious lamellar bone, haversian canal and osteocyte cells in 90 days. In conclusion, the Nano crab shell scaffold gave better acceleration in the bone healing process, also this scaffolds may provide insight into the clinical repair of large bone defects