Open AccessSTUDY THE EFFECT OF ADENOSINE DEAMINASE ENZYME IN INDUCES CYTOGENETIC AND HISTOPATHOLOGICAL CHANGES IN RATS SKIN AND EYES TREATED WITH SUMICIDIN
Author(s) -
Bushra Ibrahim Al-Qaisi
Publication year - 2000
Publication title -
the iraqi journal of veterinary medicine/al-maǧallaẗ al-ṭibbiyyaẗ al-bayṭariyyaẗ al-’irāqiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2410-7409
pISSN - 1609-5693
DOI - 10.30539/ijvm.v24i2.1169
Subject(s) - adenosine deaminase , micronucleus test , adenosine , micronucleus , endocrinology , medicine , chemistry , biology , immunology , pathology , toxicity
The present investigation aimed to study the Adenosine Deaminase activity in induction Cytogentic and histopathological change in skin and eyes of sumicidine treated rats. The study Included. 1-Adenosine deaminase activity . 2-Total serum protein. 3-Micronuclei in binucleated cell. 4-Histopathological changes in skin and eyes.
19 white male rats were used . They are randomly allocated into 3 groups : 1st group was fed 2% sumicidine for 15 days. 2nd group was fed 2% heating sumicidine for 15 days . 3rd group was kept on normal diet. Blood Adenosine Deaminase activity and Total serum protein in 1 and 2 group significantly decreased at 15 and 30 days of treated. The results
indicated that sumicidine increased significantly micronucleus in group 1 and 2. Multifocal granulomatous lesions in skin & eyes of group 1 and 2 were found characterized by highly aggregation of cells (Lymphocytes, Macrophages, Foreign body giant cells and fibroblasts).
In conclusion , Sumicidine even heated accompaying in decreased in decreased Adenosine Deaminase activity and total serum protein , in part a possible factor in the cytogenetic effect and accompanying granuloma formation in skin and eye .