Open AccessTOXIC EFFECTS OF LARGE DOSE OF QUASSIN IN NORMAL AND DEPRIVED MICROFLORA RAT GROUPS
Author(s) -
Duraid Abdulhady Abbas,
Orooba Ms Al-Shaha
Publication year - 2021
Publication title -
the iraqi journal of veterinary medicine/al-maǧallaẗ al-ṭibbiyyaẗ al-bayṭariyyaẗ al-’irāqiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2410-7409
pISSN - 1609-5693
DOI - 10.30539/ijvm.v22i1.1224
Subject(s) - dosing , body weight , kidney , physiology , food intake , stomach , antibiotics , medicine , zoology , biology , toxicology , biochemistry
Eighteen rats were divided into three equal groups. The rst group was closed orally with quassin, the second group was dosed with quassin after the gut ora were suppressed by dierent antibiotics, and the third group was served as a control. Food intake, water intake, and change in body weight were measured daily before dosing, during two weeks of dosing, and during one week after stopping dosing. Two eats from each group were killed at the end of each week, and stomach, liver, and kidney were collected for histopathologic examination.
The results show a signicant decline in daily food intake and daily change in body weight, and a signicant increase in daily water intake in both dosed groups during the dosing period. Microscopic lesions were seen in the kidneys of both dosed rats group killed at the end of first and second week