Open AccessMethod for Determining the Radiochemical Purity of Radiopharmaceuticals Based on Iodine-125, Iodine-131 and Samarium-153-oxabifor
Publication year - 2021
Publication title -
international journal of emerging trends in engineering research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 14
ISSN - 2347-3983
DOI - 10.30534/ijeter/2021/11932021
Subject(s) - radiochemistry , iodine , radionuclide , chemistry , iodide , samarium , sodium iodide , irradiation , inorganic chemistry , nuclear physics , physics , organic chemistry
iopharmaceuticals used in medicine for diagnostics, treatment, and anesthesia in various diseases. Radionuclide 125I was obtained by irradiation with neutrons of the enriched isotope 124Хе in a nuclear reactor. 131I was isolated from irradiated samples of TeO2 enriched in 130Те, and radionuclide 153Sm was obtained by irradiation of samples 152Sm2O3 in a nuclear reactor. The radiochemical purity of sodium iodide preparations labeled with 125I or 131I radionuclides was determined by the electrophoretic method, and the samarium-153-oxabifor preparation was determined by ascending paper chromatography. To determine the distribution of the activity of 125I, 131I, and 153Sm-oxabiphor by electrophoregrams and chromatograms, a γ-radiometric device Ludlum-2200 was used, which makes it possible to determine the radiochemical purity at the level of 99.9%.