Open AccessThe Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders
Author(s) -
И.В. Жуковец,
Olga Leshchenko,
Irina Andrievskaya,
Kseniya Petrova
Publication year - 2020
Publication title -
acta biomedica scientifica
Language(s) - English
Resource type - Journals
eISSN - 2587-9596
pISSN - 2541-9420
DOI - 10.29413/abs.2020-5.4.1
Subject(s) - pregnancy , miscarriage , medicine , obstetrics , gestation , medical history , prospective cohort study , physiology , gynecology , biology , genetics
Background . Spontaneous miscarriage is the most common complication of pregnancy. Obesity increases the risk of adverse pregnancy outcomes. Aim of the study . To assess the cytokine profile as a marker of spontaneous miscarriage in women with metabolic disorders in the past medical history. Materials and methods . A prospective study of 170 adolescent girls with metabolic disorders was conducted between 2000 and 2013. Assessment of menstrual and reproductive function was carried out in 86, pregnancy outcomes – in 72 women. The average age of women in reproductive age was 21.95 ± 0.2 years, BMI – 24.7 ± 3.9 kg/m2. Results . In women with early pregnancy losses and metabolic disorders in past medical history, the predictor of an early pregnancy loss is an increase in the ratio of pro- and anti-inflammatory cytokines TNF-a/IL-10 in serum at 7–8 weeks of gestation (OR = 2.29). It was determined a significant correlation between the levels of pro- and anti-inflammatory cytokines of the same name in serum and chorion (IL-10 (p = 0.000) and TNF-α/IL-10 (p = 0.001), which indicates similar changes in chorion. The activity of NF-kB in chorion was 5.75 ± 0.51 pg/ml.Conclusions . The findings suggest that the cytokine balance of pro- and anti-inflammatory cytokines in women with metabolic disorders in past medical history is an important component in the development of early pregnancy losses.