Open AccessTHE RELATIONSHIP BETWEEN CLINICO-PATHOLOGICAL PROPERTIES AND P-GLYCOPROTEIN EXPRESSION IN HIPPOCAMPAL SCLEROSIS AMONG PATIENTS WITH MESIAL TEMPORAL LOBE EPILEPSY WHO UNDERGO SELECTIVE AMYGDALOHIPPOCAMPECTOMY OPERATION
Author(s) -
Özlem Ethemoğlu,
Nalan Kayrak,
Bilge Bılgıç,
Günay Gül,
Demet Yandım Kuşçu,
Dursun Kırbaş
Publication year - 2018
Publication title -
nöropsikiyatri arşivi
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 14
ISSN - 1309-4866
DOI - 10.29399/npa.23363
Subject(s) - hippocampal sclerosis , epilepsy , temporal lobe , pathological , hippocampus , medicine , hippocampal formation , age of onset , disease , psychiatry
The overproduction of the efflux transporters in the blood-brain barrier is considered to play a role in the development of drug resistance in mesial temporal lobe epilepsy (MTLE) patients. The aim of the present study was to investigate the relationship of clinical features of patients with MTLE accompanied by hippocampal sclerosis (HS) and the p-glycoprotein (p-gp) expression and neuronal loss in the hippocampus.