Open AccessSemiquantification Study of [11C]-(R)-PK11195 PET Brain Images in Multiple Sclerosis
Author(s) -
Lucas Narciso,
Phelipi Nunes Schuck,
Caroline Machado Dartora,
Cristina Sebastião Matushita,
Jéfferson Becker,
Ana Maria Marques da Silva
Publication year - 2016
Publication title -
revista brasileira de física médica
Language(s) - English
Resource type - Journals
eISSN - 2176-8978
pISSN - 1984-9001
DOI - 10.29384/rbfm.2016.v10.n2.p39-43
Subject(s) - multiple sclerosis , white matter , medicine , nuclear medicine , radiology , magnetic resonance imaging , psychiatry
PET brain images with [11C]-(R)-PK11195 are being widely used to visualize microglial activation in vivo in neurodegenerative diseases, such as multiple sclerosis (MS). The aim of this study is to investigate the uptake behavior in juxtacortical and periventricular regions of [11C]-(R)-PK11195 PET brain images reformatted in different time intervals by applying three methods, seeking method and time interval that significantly differentiate MS patients from healthy controls. Semiquantitative SUV and SUVR methods were applied to PET images from different time intervals acquired from 10 patients with MS and 5 healthy controls. The results show significant difference between groups for SUV (p = 0.01) in 40 to 60 min interval, and SUVR with white matter as reference (p < 0.01) in 10 to 60 min interval, measured in the juxtacortical and periventricular regions.