Open AccessSubstituted Pyridopyrimidinones. Part 3. Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2-a]pyrimidin-4-one
Author(s) -
Mohamed Abass,
Mona M. Ismail,
Wafaa R. Abdel-Monem,
Aisha S. Mayas
Publication year - 2019
Publication title -
journal of the mexican chemical society
Language(s) - English
Resource type - Journals
ISSN - 2594-0317
DOI - 10.29356/jmcs.v53i2.1005
Subject(s) - chemistry , hydrazide , acetic acid , ether , pyrazole , medicinal chemistry , triazole , organic chemistry
A series of novel bis-heterocyclic ethers, containing 4Hpyrido[1,2-a]pyrimidin-4-one along with other five and six-membered heterocyclic rings, was obtained utilizing ethyl [(4-oxo-4Hpyrido[1,2-a]pyrimidin-2-yl)oxy]acetate (1), [(4-oxo-4H-pyrido[1,2a]pyrimidin-2-yl)oxy]acetic acid (2) and/or [(4-oxo-4H-pyrido[1,2a]pyrimidin-2-yl)oxy]acetohydrazide (3). Reaction of ester 1 with some ortho-hydroxy-aldehydes furnished the corresponding pyridopyrimidyloxypyrones. Reaction of ester 1 or acid 2 with 1,2-diamines led to some imidazoles. Also, some pyrazole, triazole, and oxadiazoline derivatives have been prepared from hydrazide 3.