Open AccessSpectrophotometric Determination Of Valsartan In Pure Form And In Its Pharmaceutical Preparations
Author(s) -
Qabas Naji Rashid,
Ruwaida Farman Salih
Publication year - 2021
Publication title -
mağallaẗ al-qādisiyyaaẗ li-l-ʻulūm al-ṣirfaẗ
Language(s) - English
Resource type - Journals
eISSN - 2411-3514
pISSN - 1997-2490
DOI - 10.29350/qjps.2021.26.4.1317
Subject(s) - chromogenic , molar absorptivity , reagent , chemistry , valsartan , detection limit , chromatography , correlation coefficient , spectrophotometry , nuclear chemistry , organic chemistry , mathematics , medicine , physics , statistics , blood pressure , optics , radiology
An easy, rapid and economical spectrophotometric method for determination of Valsartan (Val), by reaction with 4-chloro-7-nitrobenzofurazan (NBD-Cl) as reagent in an alkaline interemediate. This method is based on the forming of product between (Val) and the chromogenic reagent (NBD-Cl), to produce a brown color at (pH 11.9) and λmax. 470 nm. Beer’s Law is obeyed at the concentrations range of (0.4-14.8 µg/ml), with molar absorptivity of (1.05×104 L/mol.cm) and correlation coefficient 0.9827, The limit of detection was 0.557 µg/ml. The suggested method was prosperity implement to the determination of (Val) in pure form and in its pharmaceutical formulations (tablets).