Open AccessAdditional Normothermic Machine Perfusion Versus Hypothermic Machine Perfusion in Suboptimal Donor Kidney Transplantation: Protocol of a Randomized, Controlled, Open-Label Trial
Author(s) -
Elsaline Rijkse,
Sarah Bouari,
Hendrikus J. A. N. Kimenai,
Jeroen de Jonge,
Ron W. F. de Bruin,
Julia S. Slagter,
Martijn W.F. van den Hoogen,
Jan N.M. IJzermans,
Martin J. Hoogduijn,
Robert C. Minnee
Publication year - 2021
Publication title -
international journal of surgery protocols
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.291
H-Index - 4
ISSN - 2468-3574
DOI - 10.29337/ijsp.165
Subject(s) - machine perfusion , medicine , kidney transplantation , dialysis , randomized controlled trial , transplantation , kidney , donation , perfusion , population , renal function , surgery , urology , anesthesia , liver transplantation , economics , economic growth , environmental health
Ageing of the general population has led to an increase in the use of suboptimal kidneys from expanded criteria donation after brain death (ECD-DBD) and donation after circulatory death (DCD) donors. However, these kidneys have inferior graft outcomes and lower rates of immediate function. Normothermic machine perfusion (NMP) may improve outcomes of these suboptimal donor kidneys. Previous non-randomized studies have shown the safety of this technique and suggested its efficacy in improving the proportion of immediate functioning kidneys compared to static cold storage (SCS). However, its additional value to hypothermic machine perfusion (HMP), which has already been proved superior to SCS, has not yet been established.