Open AccessEffects of melatonin on liver and lung tissues of animals with bile duct ligation-induced hepatopulmonary syndrome
Author(s) -
Dal Bosco Adriane,
Colares Josieli Raskopf,
Silvia Bona,
De Andrade Lívia Barboza,
Forgiarini Jr. Luiz Alberto,
Bueno Aline Felicio,
Dias Alexandre Simões,
Marroni Norma Anair Possa
Publication year - 2021
Publication title -
journal of pulmonology and respiratory research
Language(s) - English
Resource type - Journals
ISSN - 2639-9954
DOI - 10.29328/journal.jprr.1001033
Subject(s) - hepatopulmonary syndrome , melatonin , parenchyma , lung , medicine , ligation , antioxidant , bile duct , endocrinology , cirrhosis , pathology , gastroenterology , biology , portal hypertension , biochemistry
The objective was to assess the antioxidant effect of melatonin (MLT) on liver and lung tissues of animals with bile duct ligation (BDL)-induced hepato-pulmonary syndrome (HPS). A model of BDL-induced biliary cirrhosis was used in male Wistar rats. Results suggest that MLT has an antioxidant effect on liver and lung tissues in animals with BDL-induced HPS by higher activity of antioxidant enzymes in the group HPS treated with MLT and the histological analysis of lung parenchyma showing decreased damage in this same group, including other analysis described below.