Open AccessDyslipidemia and atherogenic index of plasma in gestational diabetes mellitus with vitamin B12 deficiency.Open Access
Author(s)
Shehmeen Khan,
Sabreena Abbas,
Afsheen Abro,
Beenish Ghafar Memon,
Farhat Sultana,
Hafsa Shaikh
Publication year2022
Publication title
the professional medical journal/the professional medical journal
Resource typeJournals
PublisherINDEPENDENT MEDICAL COLLEGE
Objective: To determine frequency of vitamin B12 deficiency and dyslipidemia and calculate atherogenic index of plasma (AIP) in Gestational Diabetes mellitus (GDM). Study Design: Observational study. Setting: Department of Biochemistry, Liaquat University Jamshoro. Period: January 2018 to December 2019. Material & Methods: 216 cases of GDM were selected by inclusion criteria. Venous blood sampling collected blood sample that were centrifuged to get sera. Glucose, vitamin B12, and blood lipids were estimated by standard methods. Atherogenic Index of Plasma (AIP) was calculated as log TAG/HDLc ratio. Data was analysed by SPSS 21.0 ver. at 95% CI (P≤0.05). Results: Vitamin B12 deficiency and Dyslipidemia were noted in 151 (69.9%) and 165 (23.61%) of GDM cases respectively (P=0.0001). Vitamin B12 was found low as 156.62±82.9 ng/mL. TC (244.07±49.11), TAGs (699.4±249.5), and LDLc (137.9±40.84) were found high and HDLc (33.13±5.71) was low. High and medium risk AIP was noted in 17 (7.87%) and 29 (13.4%) of GDM cases (P=0.0001). Vitamin B12 proved negative TC (r= -0.25, P=0.02), TAG (r= -0.23, P=0.02), LDLc (r= -0.79, P=0.0001) and positive correlation with HDLc (r= 0.76, P=0.0001). Conclusion: Vitamin B12 deficiency and Dyslipidemia were noted in 151 (69.9%) and 165 (23.61%) of GDM cases respectively. High and medium risk AIP was noted in 17 (7.87%) and 29 (13.4%) of GDM cases.
Subject(s)biology , diabetes mellitus , dyslipidemia , endocrinology , gastroenterology , genetics , gestation , gestational diabetes , medicine , pregnancy , type 2 diabetes mellitus , venous blood , vitamin b12
Language(s)English
eISSN2071-7733
pISSN1024-8919
DOI10.29309/tpmj/2022.29.03.6827
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