Comparison of heparin dressing and conventional dressing in second degree burn patients in term of pain relief and wound healing.

Objective: To compare effectiveness of heparin soaked and conventional dressing in Second degree burn patients. Study Design: Randomized Controlled study. Setting: Department of Burn and Plastic Surgery, Teaching Hospital/DG Khan Medical College. Period: November 2019 to October 2020. Methodology: One hundred twenty patients fulfilling inclusion criteria were enrolled and randomly divided into two groups. Group A (60 patients) were treated with Heparin soaked Dressing and Group B (60 patients) with conventional dressing (Silver Sulphadiazine ointment 1%) and were observed up to 3-weeks of post treatment. Outcome measures were noted and was assessed by Visual Analogue scale score for pain relief and complete re-epithelization of wound (>75%) in the two groups. Significance was determined by comparing analgesia doses and total days required to heal in each dressing using chi-square test. Results: One hundred twenty patients were selected with mean age of patients was 14.4+_7.4 and male: female (62.5%:37.5%). Mean TBSA% was 12±1.80. Mean pain score in the group A for Superficial partial thickness burn (SPTB) and Deep dermal burn was 4±1 and 6±1 respectively (P-value <0.001). Total Number of days for re-epithelization in the Group A and Group B (SPTB 13±1 vs. 18 measures in term of pain relief and re-epithelization. Total analgesia requirement in the Group A and Group B (50±20 vs. 116±12mg; P-value <0.000 for Superficial Partial Thickness burn and 46±6 vs. 126±12mg; P-value <0.001 for Deep partial thickness burn) respectively. There was significant difference in Outcome. Conclusion: Heparin soaked dressing is more useful and effective in Second degree burn in term of pain relief and re-epithelization in early post burn period compared to the conventional dressing.