Open AccessSODIUM TUNGSTATE
Author(s) -
Afra Samad,
Munawar Hussain Shah,
Rana Khalid Mahmood
Publication year - 2016
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2016.23.12.1818
Subject(s) - sodium tungstate , medicine , streptozotocin , masson's trichrome stain , tungstate , h&e stain , diabetes mellitus , trichrome , intraperitoneal injection , sodium , fibrosis , pathology , staining , endocrinology , chemistry , tungsten , organic chemistry
Objectives: To determine the possible morphological effects of sodium tungstate(ST) on liver of streptozotocin (STZ) induced diabetic rabbits. Study design: This prospectivestudy was conducted on 30 rabbits of 30 weeks age. Diabetes was induced in 20 animalsby a single intraperitoneal injection of streptozotocin (50 mg/kg). 10 animals were used ascontrol. 10 diabetic rabbits were treated with sodium tungstate (ST) orally and 10 animals wereleft untreated. Histological examination of liver was performed. Setting: Place: Post graduatemedical institute lahore. Duration of study: July 2010 to August 2011. Methods: Blood glucoselevels of the rabbits were checked before and after treatment. Histological examination of liversections of 30 rabbits was performed. Sections were stained with Hematoxylin & Eosin (H & E),Trichrome and Reticulin stains separately. Results were analyzed statistically. Results: Bloodglucose levels of diabetic rabbits without Sodium Tungstate therapy were high as compared tonormal rabbits and diabetic rabbits treated with sodium tungstate. Histological examination ofliver of diabetic rabbits with Sodium Tungstate therapy did not reveal any irregular chromatinpattern or fibrosis. Conclusion: On the basis of histological examination and blood glucoselevel it is concluded that sodium tungstate is a powerful anti-diabetic agent when administeredorally with no morphological changes in liver.