Open AccessHELICOBACTER PYLORI INFECTION
Author(s) -
Adnan Qadir,
Irfan Younis,
Shahid Raza Khalid,
Zamir Butt,
Shahid Sarwar
Publication year - 2016
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2016.23.10.1730
Subject(s) - medicine , histopathology , helicobacter pylori , gold standard (test) , gastroenterology , histology , positive predicative value , helicobacter pylori infection , predictive value , pathology
Objectives: To determine diagnostic accuracy of H.pylori Stool Antigen test fordiagnosing Helicobactor pylori infection, keeping histopathology as gold standard. Studydesign: Cross sectional Validation Study. Place and duration: Study was conducted indepartment of Gastroenterology Military Hospital, Rawalpindi for six months from 1st November2014 to 30th April, 2015. Patients and methods: Serial patients presenting with dyspepsiafulfilling the inclusion criteria were entered in study program. Endoscopy was performed to takeantral biopsies for histopathology and stool was taken to test H.pylori antigen. SPSS version16.0 was used to analyze the data. Results: Eighty (72.2%) out of 110 patients were male, themean age and standard deviation was 33 ±16yrs. Three patients left study just before startingendoscopy. Eighty (74.76%) cases out of 107 patients were both positive for histology andHpSA test. Stool for H.pylori test was positive in 82 (76.63%) while histopathological diagnosiswas made in 83(77.57%) patients. The sensitivity and specificity were 96.3% and 91.66% whilepositive and negative predictive values of the stool H.pylori test were 97.56%, and 88.0%respectively. Overall the diagnostic accuracy of stool H.pylori test was 94.4% for diagnosisof H. pylori infection. Conclusion: Stool for H.pylori Antigen can be used as alternative tohistopathology due to its non-invasive nature, patient’s preference and ease of repetition.