TYPE 2 DIABETICS

Objectives: To evaluate serum cobalamin with special reference to dyslipidemiain type 2 Diabetic subjects. Study Design: Observational study Place and Duration:Department of Medicine, Isra University Hyderabad, Sindh from January 2014 to July 2014.Methodology: A sample of 107 type 2 diabetic subjects was selected according to inclusionand exclusion criteria. Cobalamin was measured on Roche Cobas e411 chemistry analyzerand blood lipoproteins by standard laboratory methods. Data was analyzed by SPSS 21.0(IBM, Incorporation, USA) using student t and Chi square tests for continuous and categoricalvariables respectively. P-value of ≤ 0.05 was taken significant. Results: Cobalamin deficiencywas noted in 51 (47.6%) of diabetics and cobalamin deficiency was associated withdyslipidemia. Mean ± SD of cobalamin in normal and reduced cobalamin groups were notedas 355±29.5 and 183±17.5 pg/ml respectively (p=0.0001). Triglycerides, total cholesterol,HDLc, LDLc and VLDLc differed significantly in the normal and reduced cobalamin subjects(p<0.001). Lipoprotein sub fractions showed a negative correlation with serum cobalamin(p≤0.02). Conclusion: Cobalamin deficiency is common in type 2 diabetics and is associatedwith dyslipidemia.