Open AccessBLADDER CARCINOMA;
Author(s) -
Anila Qureshi,
Mohammad Ahmed Azmi,
Muhammad Asif Hanif,
Muhammad Asif Hanif,
Amin Fahim
Publication year - 2016
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2016.23.05.1573
Subject(s) - medicine , cystoscopy , gross hematuria , urology , urine , gastroenterology , urinary system , surgery
Objectives: To determine the micro-RNA-145 expression in bladder cancerpatients when compared with controls and clinicopathological parameters. Study design: Acase control study. Place of Study: Samples were collected from Jinnah Postgraduate MedicalCenter Karachi and Civil Hospital Karachi. Duration of Study: January 2014 to December2014. Materials and Methods: Total of 180 patients of bladder carcinoma were divided intothree groups according to WHO/1998 classification system. PUNLMP in group-I, PUCLG ingroup-II, PUCHG in group-III were compared with 60 healthy controls in group-IV. Results:The results showed that miR-145 expression was decreased in patients with bladder cancerwhen compared with controls. Down regulation was more obvious in BC cases with increasinggrade. A significant correlation was found between the expression of miR-145 with microscopichematuria, cystoscopy and staging. Whereas no association was found with age, frequency,urgency, flank pain, gross hematuria, urine pH, and ultrasound. Conclusion: miR-145 is downregulated in BC patients with significant correlation with microscopic hematuria, cystoscopyand staging.